Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E

Landomycin E (LE) is an angucycline antibiotic produced by Streptomyces globisporus. Previously, we have shown a broad anticancer activity of LE which is, in contrast to the structurally related and clinically used anthracycline doxorubicin (Dx), only mildly affected by multidrug resistance-mediated...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Panchuk, Rostyslav R., Lehka, Lilya V., Matselyukh, Bohdan P., Rohr, Jurgen, Kril’, Iryna J., Herbacek, Irene, Heffeter, Petra, Stoika, Rostyslav S., Berger, Walter
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552372/
https://ncbi.nlm.nih.gov/pubmed/28189848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.02.024
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