ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

Parkinson's disease is assumed to be caused by mitochondrial dysfunction in the affected dopaminergic neurons in the brain. We have recently created small chemicals, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption. By contrast, agonistic ligands of ERRs (estrogen r...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Nakano, Masaki, Imamura, Hiromi, Sasaoka, Norio, Yamamoto, Masamichi, Uemura, Norihito, Shudo, Toshiyuki, Fuchigami, Tomohiro, Takahashi, Ryosuke, Kakizuka, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552266/
https://ncbi.nlm.nih.gov/pubmed/28780078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.07.024
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