ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

Parkinson's disease is assumed to be caused by mitochondrial dysfunction in the affected dopaminergic neurons in the brain. We have recently created small chemicals, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption. By contrast, agonistic ligands of ERRs (estrogen r...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Nakano, Masaki, Imamura, Hiromi, Sasaoka, Norio, Yamamoto, Masamichi, Uemura, Norihito, Shudo, Toshiyuki, Fuchigami, Tomohiro, Takahashi, Ryosuke, Kakizuka, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552266/
https://ncbi.nlm.nih.gov/pubmed/28780078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.07.024
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