ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

Parkinson's disease is assumed to be caused by mitochondrial dysfunction in the affected dopaminergic neurons in the brain. We have recently created small chemicals, KUSs (Kyoto University Substances), which can reduce cellular ATP consumption. By contrast, agonistic ligands of ERRs (estrogen r...

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Detalhes bibliográficos
Main Authors: Masaki Nakano, Hiromi Imamura, Norio Sasaoka, Masamichi Yamamoto, Norihito Uemura, Toshiyuki Shudo, Tomohiro Fuchigami, Ryosuke Takahashi, Akira Kakizuka
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-08-01
Colecção:EBioMedicine
Assuntos:
ATP
Parkinson's disease
ER stress
Dopaminergic neurons
Mitochondria
α-Synuclein
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2352396417302979
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