Cell cycle–dependent spatial segregation of telomerase from sites of DNA damage

Telomerase can generate a novel telomere at DNA double-strand breaks (DSBs), an event called de novo telomere addition. How this activity is suppressed remains unclear. Combining single-molecule imaging and deep sequencing, we show that the budding yeast telomerase RNA (TLC1 RNA) is spatially segreg...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Cell Biol
Main Authors: Ouenzar, Faissal, Lalonde, Maxime, Laprade, Hadrien, Morin, Geneviève, Gallardo, Franck, Tremblay-Belzile, Samuel, Chartrand, Pascal
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551704/
https://ncbi.nlm.nih.gov/pubmed/28637749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610071
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