TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

The yeast telomerase holoenzyme, which adds telomeric repeats at the chromosome ends, is composed of the TLC1 RNA and the associated proteins Est1, Est2 and Est3. To study the biogenesis of telomerase in endogenous conditions, we performed fluorescent in situ hybridization on the native TLC1 RNA. We...

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Main Authors: Gallardo, Franck, Olivier, Catherine, Dandjinou, Alain T, Wellinger, Raymund J, Chartrand, Pascal
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2008
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265757/
https://ncbi.nlm.nih.gov/pubmed/18273059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.21
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