TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

The yeast telomerase holoenzyme, which adds telomeric repeats at the chromosome ends, is composed of the TLC1 RNA and the associated proteins Est1, Est2 and Est3. To study the biogenesis of telomerase in endogenous conditions, we performed fluorescent in situ hybridization on the native TLC1 RNA. We...

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Hlavní autoři: Gallardo, Franck, Olivier, Catherine, Dandjinou, Alain T, Wellinger, Raymund J, Chartrand, Pascal
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265757/
https://ncbi.nlm.nih.gov/pubmed/18273059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.21
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