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Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model

In Saccharomyces cerevisiae, the Ku heterodimer contributes to telomere maintenance as a component of telomeric chromatin and as an accessory subunit of telomerase. How Ku binding to double-stranded DNA (dsDNA) and to telomerase RNA (TLC1) promotes its telomeric functions is incompletely understood....

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Detalhes bibliográficos
Main Authors: Pfingsten, Jennifer S., Goodrich, Karen J., Taabazuing, Cornelius, Ouenzar, Faissal, Chartrand, Pascal, Cech, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327133/
https://ncbi.nlm.nih.gov/pubmed/22365814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.01.033
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