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Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model
In Saccharomyces cerevisiae, the Ku heterodimer contributes to telomere maintenance as a component of telomeric chromatin and as an accessory subunit of telomerase. How Ku binding to double-stranded DNA (dsDNA) and to telomerase RNA (TLC1) promotes its telomeric functions is incompletely understood....
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3327133/ https://ncbi.nlm.nih.gov/pubmed/22365814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.01.033 |
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