Breaching peripheral tolerance promotes the production of HIV-1–neutralizing antibodies

A subset of characterized HIV-1 broadly neutralizing antibodies (bnAbs) are polyreactive with additional specificities for self-antigens and it has been proposed immunological tolerance may present a barrier to their participation in protective humoral immunity. We address this hypothesis by immuniz...

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Publicado en:J Exp Med
Autores principales: Schroeder, Kristin M.S., Agazio, Amanda, Strauch, Pamela J., Jones, Sean T., Thompson, Scott B., Harper, Michael S., Pelanda, Roberta, Santiago, Mario L., Torres, Raul M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551567/
https://ncbi.nlm.nih.gov/pubmed/28698284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161190
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