Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

The calcium-sensing receptor (CaSR) is a family C G-protein–coupled receptor that plays a pivotal role in extracellular calcium homeostasis. The CaSR is also highly expressed in pancreatic islet α- and β-cells that secrete glucagon and insulin, respectively. To determine whether the CaSR may influen...

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Publicat a:Endocrinology
Autors principals: Babinsky, Valerie N., Hannan, Fadil M., Ramracheya, Reshma D., Zhang, Quan, Nesbit, M. Andrew, Hugill, Alison, Bentley, Liz, Hough, Tertius A., Joynson, Elizabeth, Stewart, Michelle, Aggarwal, Abhishek, Prinz-Wohlgenannt, Maximilian, Gorvin, Caroline M., Kallay, Enikö, Wells, Sara, Cox, Roger D., Richards, Duncan, Rorsman, Patrik, Thakker, Rajesh V.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551547/
https://ncbi.nlm.nih.gov/pubmed/28575322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00111
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