Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss

No therapies exist to prevent neuronal deficits in multiple sclerosis (MS), because the molecular mechanism responsible for the progressive neurodegeneration is unknown. We previously showed that axon injury-induced neuronal endoplasmic reticulum (ER) stress plays an important role in retinal gangli...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Huang, Haoliang, Miao, Linqing, Liang, Feisi, Liu, Xiaodong, Xu, Lin, Teng, Xiuyin, Wang, Qizhao, Ridder, William H, Shindler, Kenneth S, Sun, Yang, Hu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550873/
https://ncbi.nlm.nih.gov/pubmed/28726788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.329
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