The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration

Using mouse optic nerve (ON) crush as a CNS injury model, we and others have found that activation of the mammalian target of rapamycin complex 1 (mTORC1) in mature retinal ganglion cells by deletion of the negative regulators, phosphatase and tensin homolog (PTEN) and tuberous sclerosis 1, promotes...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yang, Liu, Miao, Linqing, Liang, Feisi, Huang, Haoliang, Teng, Xiuyin, Li, Shaohua, Nuriddinov, Jaloliddin, Selzer, Michael E., Hu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4228696/
https://ncbi.nlm.nih.gov/pubmed/25382660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6416
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