Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia

Here we have explored whether inhibition of autophagy can be used as a treatment strategy for acute myeloid leukemia (AML). Steady-state autophagy was measured in leukemic cell lines and primary human CD34(+) AML cells with a large variability in basal autophagy between AMLs observed. The autophagy...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Folkerts, Hendrik, Hilgendorf, Susan, Wierenga, Albertus T J, Jaques, Jennifer, Mulder, André B, Coffer, Paul J, Schuringa, Jan Jacob, Vellenga, Edo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550863/
https://ncbi.nlm.nih.gov/pubmed/28703806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.317
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