In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity

HIV-1 Tat transactivates viral genes through strong interaction with TAR RNA. The stem-loop bulged region of TAR consisting of three nucleotides at the position 23–25 and the loop region consisting of six nucleotides at the position 30–35 are essential for viral transactivation. The arginine motif o...

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Dades bibliogràfiques
Publicat a:Front Microbiol
Autors principals: Ronsard, Larance, Rai, Tripti, Rai, Devesh, Ramachandran, Vishnampettai G., Banerjea, Akhil C.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550727/
https://ncbi.nlm.nih.gov/pubmed/28848502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.01467
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