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HIV-1 Tat potently stabilises Mdm2 and enhances viral replication

Murine double minute 2 (Mdm2) is known to enhance the transactivation potential of human immunodeficiency virus (HIV-1) Tat protein by causing its ubiquitination. However, the regulation of Mdm2 during HIV-1 infection and its implications for viral replication have not been well studied. Here, we sh...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Raja, Rameez, Ronsard, Larance, Lata, Sneh, Trivedi, Shubhendu, Banerjea, Akhil C.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509382/
https://ncbi.nlm.nih.gov/pubmed/28468838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160825
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