Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase

Although cellular prion protein PrP(C) is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, we here show that PrP(C) displays the intrinsic capacity to protect neuronal cells from a pro-inflammatory T...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Ezpeleta, Juliette, Boudet-Devaud, François, Pietri, Mathéa, Baudry, Anne, Baudouin, Vincent, Alleaume-Butaux, Aurélie, Dagoneau, Nathalie, Kellermann, Odile, Launay, Jean-Marie, Schneider, Benoit
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550509/
https://ncbi.nlm.nih.gov/pubmed/28794434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08110-x
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