Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase

Although cellular prion protein PrP(C) is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, we here show that PrP(C) displays the intrinsic capacity to protect neuronal cells from a pro-inflammatory T...

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Vydáno v:Sci Rep
Hlavní autoři: Ezpeleta, Juliette, Boudet-Devaud, François, Pietri, Mathéa, Baudry, Anne, Baudouin, Vincent, Alleaume-Butaux, Aurélie, Dagoneau, Nathalie, Kellermann, Odile, Launay, Jean-Marie, Schneider, Benoit
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550509/
https://ncbi.nlm.nih.gov/pubmed/28794434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08110-x
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