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Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates
In neurodegenerative diseases, seeding is a process initiated by the internalization of exogenous protein aggregates. Multiple pathways for internalization of aggregates have been proposed, including direct membrane penetration and endocytosis. To decipher the seeding mechanisms of alpha-synuclein (...
Enregistré dans:
| Publié dans: | Sci Rep |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5550496/ https://ncbi.nlm.nih.gov/pubmed/28794446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08149-w |
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