Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant and anti-...

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Pubblicato in:Sci Rep
Autori principali: Yamanashi, Takehiko, Iwata, Masaaki, Kamiya, Naho, Tsunetomi, Kyohei, Kajitani, Naofumi, Wada, Nodoka, Iitsuka, Takahiro, Yamauchi, Takahira, Miura, Akihiko, Pu, Shenghong, Shirayama, Yukihiko, Watanabe, Ken, Duman, Ronald S., Kaneko, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550422/
https://ncbi.nlm.nih.gov/pubmed/28794421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08055-1
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