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Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome

RNA transcripts containing expanded nucleotide repeats cause many incurable diseases via various mechanisms. One such disorder, fragile X-associated tremor ataxia syndrome (FXTAS), is caused by a noncoding r(CGG) repeat expansion (r(CGG)(exp)) that (i) sequesters proteins involved in RNA metabolism...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Yang, Wang-Yong, He, Fang, Strack, Rita L., Oh, Seok Yoon, Frazer, Michelle, Jaffrey, Samie R., Todd, Peter K., Disney, Matthew D.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549791/
https://ncbi.nlm.nih.gov/pubmed/27276216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00147
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