RADX promotes genome stability and modulates chemosensitivity by regulating RAD51 at replication forks

RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork protection. Defects in these functions cause genomic instability and tumorigenesis, but also generate hypersensitivity to cancer therapeutics. Here we describe the identification of RADX as an RPA-like, single...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Dungrawala, Huzefa, Bhat, Kamakoti P., Le Meur, Rémy, Chazin, Walter J., Ding, Xia, Sharan, Shyam K., Wessel, Sarah R., Sathe, Aditya A., Zhao, Runxiang, Cortez, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548441/
https://ncbi.nlm.nih.gov/pubmed/28735897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.023
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