RADX promotes genome stability and modulates chemosensitivity by regulating RAD51 at replication forks

RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork protection. Defects in these functions cause genomic instability and tumorigenesis, but also generate hypersensitivity to cancer therapeutics. Here we describe the identification of RADX as an RPA-like, single...

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Publicado no:Mol Cell
Main Authors: Dungrawala, Huzefa, Bhat, Kamakoti P., Le Meur, Rémy, Chazin, Walter J., Ding, Xia, Sharan, Shyam K., Wessel, Sarah R., Sathe, Aditya A., Zhao, Runxiang, Cortez, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548441/
https://ncbi.nlm.nih.gov/pubmed/28735897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.023
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