RADX promotes genome stability and modulates chemosensitivity by regulating RAD51 at replication forks

RAD51 promotes homology-directed repair (HDR), replication fork reversal, and stalled fork protection. Defects in these functions cause genomic instability and tumorigenesis, but also generate hypersensitivity to cancer therapeutics. Here we describe the identification of RADX as an RPA-like, single...

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Publicado en:Mol Cell
Autores principales: Dungrawala, Huzefa, Bhat, Kamakoti P., Le Meur, Rémy, Chazin, Walter J., Ding, Xia, Sharan, Shyam K., Wessel, Sarah R., Sathe, Aditya A., Zhao, Runxiang, Cortez, David
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548441/
https://ncbi.nlm.nih.gov/pubmed/28735897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.06.023
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