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Exploiting sequence and stability information for directing nanobody stability engineering

BACKGROUND: Variable domains of camelid heavy-chain antibodies, commonly named nanobodies, have high biotechnological potential. In view of their broad range of applications in research, diagnostics and therapy, engineering their stability is of particular interest. One important aspect is the impro...

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Dades bibliogràfiques
Publicat a:Biochim Biophys Acta
Autors principals: Kunz, Patrick, Flock, Tilman, Soler, Nicolas, Zaiss, Moritz, Vincke, Cécile, Sterckx, Yann, Kastelic, Damjana, Muyldermans, Serge, Hoheisel, Jörg D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548252/
https://ncbi.nlm.nih.gov/pubmed/28642127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.06.014
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