Exploiting sequence and stability information for directing nanobody stability engineering

BACKGROUND: Variable domains of camelid heavy-chain antibodies, commonly named nanobodies, have high biotechnological potential. In view of their broad range of applications in research, diagnostics and therapy, engineering their stability is of particular interest. One important aspect is the impro...

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Pubblicato in:Biochim Biophys Acta
Autori principali: Kunz, Patrick, Flock, Tilman, Soler, Nicolas, Zaiss, Moritz, Vincke, Cécile, Sterckx, Yann, Kastelic, Damjana, Muyldermans, Serge, Hoheisel, Jörg D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548252/
https://ncbi.nlm.nih.gov/pubmed/28642127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.06.014
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