Exploiting sequence and stability information for directing nanobody stability engineering

BACKGROUND: Variable domains of camelid heavy-chain antibodies, commonly named nanobodies, have high biotechnological potential. In view of their broad range of applications in research, diagnostics and therapy, engineering their stability is of particular interest. One important aspect is the impro...

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Publicado en:Biochim Biophys Acta
Main Authors: Kunz, Patrick, Flock, Tilman, Soler, Nicolas, Zaiss, Moritz, Vincke, Cécile, Sterckx, Yann, Kastelic, Damjana, Muyldermans, Serge, Hoheisel, Jörg D.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548252/
https://ncbi.nlm.nih.gov/pubmed/28642127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.06.014
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