Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

BACKGROUND: DC derived-exosomes are nanomeric vesicles harboring functional MHC/peptide complexes capable of promoting T cell immune responses and tumor rejection. Here we report the feasability and safety of the first Phase I clinical trial using autologous exosomes pulsed with MAGE 3 peptides for...

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Bibliografische gegevens
Hoofdauteurs: Escudier, Bernard, Dorval, Thierry, Chaput, Nathalie, André, Fabrice, Caby, Marie-Pierre, Novault, Sophie, Flament, Caroline, Leboulaire, Christophe, Borg, Christophe, Amigorena, Sebastian, Boccaccio, Catherine, Bonnerot, Christian, Dhellin, Olivier, Movassagh, Mojgan, Piperno, Sophie, Robert, Caroline, Serra, Vincent, Valente, Nancy, Le Pecq, Jean-Bernard, Spatz, Alain, Lantz, Olivier, Tursz, Thomas, Angevin, Eric, Zitvogel, Laurence
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2005
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC554765/
https://ncbi.nlm.nih.gov/pubmed/15740633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-3-10
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