Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2

Mitogen-activated protein (MAP) kinase substrates are believed to require consensus docking motifs (D-site, F-site) to engage and facilitate efficient site-specific phosphorylation at specific serine/threonine-proline sequences by their cognate kinases. In contrast to other MAP kinase substrates, th...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Piserchio, Andrea, Warthaka, Mangalika, Kaoud, Tamer S., Callaway, Kari, Dalby, Kevin N., Ghose, Ranajeet
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547609/
https://ncbi.nlm.nih.gov/pubmed/28716922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702973114
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