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Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways

Osthole, a natural coumarin found in traditional Chinese medicinal plants, has shown multiple biological activities. In the present study, we investigated the preventive effects of osthole on inflammatory bowel disease (IBD). Colitis was induced in mice by infusing TNBS into the colonic lumen. Befor...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Sun, Wu, Cai, Yun, Zhang, Xin-xin, Chen, Hao, Lin, Yan-die, Li, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547558/
https://ncbi.nlm.nih.gov/pubmed/28603288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.71
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