Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine

BACKGROUND: C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-terminal tail tyrosine which stabilizes SFKs in a closed inactive conformation by enga...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Advani, Gahana, Lim, Ya Chee, Catimel, Bruno, Lio, Daisy Sio Seng, Ng, Nadia L. Y., Chüeh, Anderly C., Tran, Mai, Anasir, Mohd Ishtiaq, Verkade, Heather, Zhu, Hong-Jian, Turk, Benjamin E., Smithgall, Thomas E., Ang, Ching-Seng, Griffin, Michael, Cheng, Heung-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547543/
https://ncbi.nlm.nih.gov/pubmed/28784162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-017-0186-x
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