Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate

C-terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor function by phosphorylating the C-terminal regulatory tyrosine of the Src-family kinases (SFKs). The phosphorylation suppresses their activity and oncogenic action. In addition to phosphorylating SFKs, CHK also performs non-SF...

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Detalhes bibliográficos
Main Authors: Ia, Kim K., Jeschke, Grace R., Deng, Yang, Kamaruddin, Mohd Aizuddin, Williamson, Nicholas A., Scanlon, Denis B., Culvenor, Janetta G., Hossain, Mohammed Iqbal, Purcell, Anthony W., Liu, Sheng, Zhu, Hong-Jian, Catimel, Bruno, Turk, Benjamin E., Cheng, Heung-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156789/
https://ncbi.nlm.nih.gov/pubmed/21699177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2001938
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