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Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate
C-terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor function by phosphorylating the C-terminal regulatory tyrosine of the Src-family kinases (SFKs). The phosphorylation suppresses their activity and oncogenic action. In addition to phosphorylating SFKs, CHK also performs non-SF...
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Main Authors: | , , , , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2011
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156789/ https://ncbi.nlm.nih.gov/pubmed/21699177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2001938 |
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