Aromatase inhibitory activity of 1,4-naphthoquinone derivatives and QSAR study

A series of 2-amino(chloro)-3-chloro-1,4-naphthoquinone derivatives (1-11) were investigated for their aromatase inhibitory activities. 1,4-Naphthoquinones 1 and 4 were found to be the most potent compounds affording IC(50 )values 5.2 times lower than the reference drug, ketoconazole. A quantitative...

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Publicado en:EXCLI J
Autores principales: Prachayasittikul, Veda, Pingaew, Ratchanok, Worachartcheewan, Apilak, Sitthimonchai, Somkid, Nantasenamat, Chanin, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong
Formato: Artigo
Lenguaje:Inglês
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547393/
https://ncbi.nlm.nih.gov/pubmed/28827987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17179/excli2017-309
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