12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets

CONTEXT: The 12-lipoxygenase (12-LO) pathway produces proinflammatory metabolites, and its activation is implicated in islet inflammation associated with type 1 and type 2 diabetes (T2D). OBJECTIVES: We aimed to test the efficacy of ML355, a highly selective, small molecule inhibitor of 12-LO, for t...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Ma, Kaiwen, Xiao, An, Park, So Hyun, Glenn, Lindsey, Jackson, Laura, Barot, Tatvam, Weaver, Jessica R., Taylor-Fishwick, David A., Luci, Diane K., Maloney, David J., Mirmira, Raghavendra G., Imai, Yumi, Nadler, Jerry L.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Clinical Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546865/
https://ncbi.nlm.nih.gov/pubmed/28609824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-00267
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