Medullary Thyroid Carcinoma in MEN2A: ATA Moderate- or High-Risk RET Mutations Do Not Predict Disease Aggressiveness

CONTEXT: High-risk RET mutations (codon 634) are associated with earlier development of medullary thyroid carcinoma (MTC) and presumed increased aggressiveness compared with moderate-risk RET mutations. OBJECTIVE: To determine whether high-risk RET mutations are more aggressive. DESIGN: Retrospectiv...

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Dades bibliogràfiques
Publicat a:J Clin Endocrinol Metab
Autors principals: Voss, Rachel K., Feng, Lei, Lee, Jeffrey E., Perrier, Nancy D., Graham, Paul H., Hyde, Samuel M., Nieves-Munoz, Frances, Cabanillas, Maria E., Waguespack, Steven G., Cote, Gilbert J., Gagel, Robert F., Grubbs, Elizabeth G.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2017
Matèries:
Clinical Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546858/
https://ncbi.nlm.nih.gov/pubmed/28609830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2017-00317
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