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Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1
Isocitrate dehydrogenase (IDH) plays an indispensable role in the tricarboxylic acid cycle, and IDH mutations are present in nearly 75% of glioma and 20% of acute myeloid leukemia. One IDH1R132H inhibitor (clomifene citrate) was found by virtual screening method, which can selectively suppress mutan...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546478/ https://ncbi.nlm.nih.gov/pubmed/28498812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17464 |
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