Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1

Isocitrate dehydrogenase (IDH) plays an indispensable role in the tricarboxylic acid cycle, and IDH mutations are present in nearly 75% of glioma and 20% of acute myeloid leukemia. One IDH1R132H inhibitor (clomifene citrate) was found by virtual screening method, which can selectively suppress mutan...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zheng, Mengzhu, Sun, Weiguang, Gao, Suyu, Luan, Shanshan, Li, Dan, Chen, Renqi, Zhang, Qian, Chen, Lixia, Huang, Jiangeng, Li, Hua
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546478/
https://ncbi.nlm.nih.gov/pubmed/28498812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17464
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