A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity

Kidney-type glutaminase (KGA), a mitochondrial enzyme converting glutamine to glutamate for energy supply, was over-expressed in many cancers and had been regarded as a promising therapeutic target in recent years. Structure-based virtual ligand screening predicted physapubescin K, a new withanolide...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Wu, Canrong, Zheng, Mengzhu, Gao, Suyu, Luan, Shanshan, Cheng, Li, Wang, Liqing, Li, Jiachen, Chen, Lixia, Li, Hua
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2017
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768343/
https://ncbi.nlm.nih.gov/pubmed/29371926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23058
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