Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Proteasomal degradation of topoisomerase I (topoI) is one of the most remarkable cellular phenomena observed in response to camptothecin (CPT). Importantly, the rate of topoI degradation is linked to CPT resistance. Formation of the topoI-DNA-CPT cleavable complex inhibits DNA re-ligation resulting...

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Udgivet i:Oncotarget
Main Authors: Ando, Koji, Shah, Ankur K., Sachdev, Vibhu, Kleinstiver, Benjamin P., Taylor-Parker, Julian, Welch, Moira M., Hu, Yiheng, Salgia, Ravi, White, Forest M., Parvin, Jeffrey D., Ozonoff, Al, Rameh, Lucia E., Joung, J. Keith, Bharti, Ajit K.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546437/
https://ncbi.nlm.nih.gov/pubmed/28415827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16376
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