Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Proteasomal degradation of topoisomerase I (topoI) is one of the most remarkable cellular phenomena observed in response to camptothecin (CPT). Importantly, the rate of topoI degradation is linked to CPT resistance. Formation of the topoI-DNA-CPT cleavable complex inhibits DNA re-ligation resulting...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ando, Koji, Shah, Ankur K., Sachdev, Vibhu, Kleinstiver, Benjamin P., Taylor-Parker, Julian, Welch, Moira M., Hu, Yiheng, Salgia, Ravi, White, Forest M., Parvin, Jeffrey D., Ozonoff, Al, Rameh, Lucia E., Joung, J. Keith, Bharti, Ajit K.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546437/
https://ncbi.nlm.nih.gov/pubmed/28415827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16376
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados