Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors

Phosphorylation is the most extensively studied posttranslational modification of proteins. There are approximately 500 kinases known in the human genome. The kinase-activated pathways regulate almost every aspect of cell function and a deregulated kinase cascade leads to impaired cellular function....

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Publicado no:J Histochem Cytochem
Main Authors: Ando, Koji, Tohme, Yara Hamade, Srinivasiah, Adithi, Taylor-Parker, Julian, Harrington, Yevgeniya, Shah, Ankur K., Oki, Eiji, Brahmandam, Mohan, Bharti, Ajit K.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071180/
https://ncbi.nlm.nih.gov/pubmed/29587004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155418766503
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