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Directed evolution of the forkhead-associated domain to generate anti-phosphospecific reagents by phage-display

While affinity reagents are valuable tools for monitoring protein phosphorylation and studying signaling events in cells, generating them through immunization of animals with phosphopeptides is expensive, laborious and time consuming. An attractive alternative is to use protein evolution techniques...

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Hlavní autoři: Pershad, Kritika, Wypisniak, Karolina, Kay, Brian K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488158/
https://ncbi.nlm.nih.gov/pubmed/22985966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.09.006
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