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Prevention of mammary tumor progression by silencing HoxA1 via intraductal injection of nanoparticle-formulated siRNA

With advances in screening, the incidence of detection of premalignant breast lesions has increased in recent decades; however, treatment options remain limited to surveillance or surgical removal by lumpectomy or mastectomy. We hypothesized that disease progression could be blocked by RNA interfere...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Brock, Amy, Krause, Silva, Li, Hu, Kowalski, Marek, Goldberg, Michael S., Collins, James J., Ingber, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546412/
https://ncbi.nlm.nih.gov/pubmed/24382894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3007048
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