Aβ-Specific Th2 cells Provide Cognitive and Pathological Benefits to Alzheimer’s Mice without Infiltrating the CNS

We have found that a small number of purified Th2-biased Aβ-specific T cells are sufficient to provide profound cognitive and pathological benefits in an APP+PS1 mouse model for Alzheimer’s disease. Six weeks after receiving T cell infusions, cognitively-impaired mice performed significantly better...

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Библиографические подробности
Опубликовано в: :Neurobiol Dis
Главные авторы: Cao, Chuanhai, Arendash, Gary W., Dickson, Alexander, Mamcarz, Malgorzata B., Lin, Xiaoyang, Ethell, Douglas W.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546306/
https://ncbi.nlm.nih.gov/pubmed/19167499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2008.12.015
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