Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination

Although the mammalian target of rapamycin (mTOR) is an essential regulator of developmental oligodendrocyte differentiation and myelination, oligodendrocyte-specific deletion of tuberous sclerosis complex (TSC), a major upstream inhibitor of mTOR, surprisingly also leads to hypomyelination during C...

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Bibliographic Details
Published in:J Neurosci
Main Authors: McLane, Lauren E., Bourne, Jennifer N., Evangelou, Angelina V., Khandker, Luipa, Macklin, Wendy B., Wood, Teresa L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546116/
https://ncbi.nlm.nih.gov/pubmed/28694334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3454-16.2017
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