The MNK–eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

Injury-induced sensitization of nociceptors contributes to pain states and the development of chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of rapamycin and mitogen-activated protein kinase (MAPK) pathways blocks the development of nociceptor sensitization....

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Pubblicato in:J Neurosci
Autori principali: Moy, Jamie K., Khoutorsky, Arkady, Asiedu, Marina N., Black, Bryan J., Kuhn, Jasper L., Barragán-Iglesias, Paulino, Megat, Salim, Burton, Michael D., Burgos-Vega, Carolina C., Melemedjian, Ohannes K., Boitano, Scott, Vagner, Josef, Gkogkas, Christos G., Pancrazio, Joseph J., Mogil, Jeffrey S., Dussor, Gregory, Sonenberg, Nahum, Price, Theodore J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546114/
https://ncbi.nlm.nih.gov/pubmed/28674170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0220-17.2017
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