Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side

Metabolite transport is a major function of the retinal pigment epithelium (RPE) to support the neural retina. RPE dysfunction plays a significant role in retinal degenerative diseases. We have used mass spectrometry with (13)C tracers to systematically study nutrient consumption and metabolite tran...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Chao, Jennifer R., Knight, Kaitlen, Engel, Abbi L., Jankowski, Connor, Wang, Yekai, Manson, Megan A., Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Hurley, James B., Du, Jianhai
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546030/
https://ncbi.nlm.nih.gov/pubmed/28615447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788422
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