Endoplasmic reticulum–associated degradation of the renal potassium channel, ROMK, leads to type II Bartter syndrome

Type II Bartter syndrome is caused by mutations in the renal outer medullary potassium (ROMK) channel, but the molecular mechanisms underlying this disease are poorly defined. To rapidly screen for ROMK function, we developed a yeast expression system and discovered that yeast cells lacking endogeno...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: O'Donnell, Brighid M., Mackie, Timothy D., Subramanya, Arohan R., Brodsky, Jeffrey L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546024/
https://ncbi.nlm.nih.gov/pubmed/28630040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.786376
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