The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

The mammalian imprinted Dlk1-Gtl2 locus produces multiple non-coding RNAs (ncRNAs) from the maternally inherited allele, including the largest miRNA cluster in the mammalian genome. This locus has characterized functions in some types of stem cell, but its role in hematopoietic stem cells (HSCs) is...

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Publicat a:Cell Stem Cell
Autors principals: Qian, Pengxu, He, Xi C., Paulson, Ariel, Li, Zhenrui, Tao, Fang, Perry, John M., Guo, Fengli, Zhao, Meng, Zhi, Lei, Venkatraman, Aparna, Haug, Jeffrey S., Parmely, Tari, Li, Hua, Dobrowsky, Rick T., Ding, Wen-Xing, Kono, Tomohiro, Ferguson-Smith, Anne C., Li, Linheng
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545934/
https://ncbi.nlm.nih.gov/pubmed/26627594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.11.001
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