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Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders

Tic disorders affect ~5% of the population and are frequently comorbid with obsessive-compulsive disorder, autism, and attention deficit disorder. Histamine dysregulation has been identified as a rare genetic cause of tic disorders; mice with a knockout of the histidine decarboxylase (Hdc) gene repr...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Rapanelli, M, Frick, L, Pogorelov, V, Ohtsu, H, Bito, H, Pittenger, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545743/
https://ncbi.nlm.nih.gov/pubmed/28117842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.290
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