Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes Specificity

The conserved NAD(+)-dependent deacylase SIRT1 plays pivotal, sometimes contrasting, roles in diverse physiological and pathophysiological conditions. In this study, we uncover a tissue-restricted isoform of SIRT1 (SIRT1-ΔE2) that lacks exon 2 (E2). Candidate-based screening of SIRT1 substrates demo...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Deota, Shaunak, Chattopadhyay, Tandrika, Ramachandran, Deepti, Armstrong, Eric, Camacho, Beatriz, Maniyadath, Babukrishna, Fulzele, Amit, Gonzalez-de-Peredo, Anne, Denu, John M., Kolthur-Seetharam, Ullas
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545126/
https://ncbi.nlm.nih.gov/pubmed/28355560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.012
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk