Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria

Anabolic and catabolic signaling mediated via mTOR and AMPK (AMP-activated kinase) have to be intrinsically coupled to mitochondrial functions for maintaining homeostasis and mitigate cellular/organismal stress. Although glutamine is known to activate mTOR, whether and how differential mitochondrial...

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Veröffentlicht in:Mol Cell Biol
Hauptverfasser: Shaw, Eisha, Talwadekar, Manasi, Rashida, Zeenat, Mohan, Nitya, Acharya, Aishwarya, Khatri, Subhash, Laxman, Sunil, Kolthur-Seetharam, Ullas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944470/
https://ncbi.nlm.nih.gov/pubmed/31685549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00212-19
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