The clonal evolution of two distinct T315I-positive BCR-ABL1 subclones in a Philadelphia-positive acute lymphoblastic leukemia failing multiple lines of therapy: a case report

BACKGROUND: The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is particularly challenging since first and second-generation Tyrosine Kinase Inhibitor...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: De Benedittis, Caterina, Papayannidis, Cristina, Venturi, Claudia, Abbenante, Maria Chiara, Paolini, Stefania, Parisi, Sarah, Sartor, Chiara, Cavo, Michele, Martinelli, Giovanni, Soverini, Simona
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545087/
https://ncbi.nlm.nih.gov/pubmed/28779753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3511-2
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