In vivo genetic manipulation of inner ear connexin expression by bovine adeno-associated viral vectors

We have previously shown that in vitro transduction with bovine adeno–associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin–deficient mice that are models DFNB1 nonsyndromic hearing loss and deafness. The aims of...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Crispino, Giulia, Galindo Ramirez, Fabian, Campioni, Matteo, Zorzi, Veronica, Praetorius, Mark, Di Pasquale, Giovanni, Chiorini, John A., Mammano, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544751/
https://ncbi.nlm.nih.gov/pubmed/28779115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06759-y
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